Objective This research work was carried out to evaluate the antimicrobial activities of different parts of Carica papaya and their phytochemical screening. Method Ethanol and hot water were used to extract the active compounds from dry leaves, wet leaves and dry seeds of Carica papaya. The phytochemical analysis of the different parts of the plant was also carried out to determine the active ingredients present in these extracts. The antimicrobial activities of different solvents of these extracts were determined against bacterial and fungal isolates by observing the zones of inhibition. The bacterial isolates used were Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, Streptococcus pneumonia and Bacillus subtilis, while the fungi include Candida albicans and Fusarium monoliforme. Results obtained showed that the ethanolic extracts showed more antibacterial activities than the aqueous extracts. The ethanolic extract of dry seed of Carica papaya showed grater activities against all the bacterial isolates except Streptococcus pneumoniae. The zones of inhibition ranged from 9 to 30 for all the plant extracts, while the Minimum Inhibition Concentration (MIC) ranged from 50 to 200mg/mL. The phytochemical analysis showed that the plant extracts contained these active ingredients in varying concentrations; alkaloids, saponin, tannin, terpenoid and flavonoids.