This image is part of a series that was created for an open textbook, Cell Biology, Genetics and Biochemistry for PreClinical Students. The textbook will be available Late 2021.
Kindred Grey (2021). "Nucleotide base salvage."CC BY 4.0.
Hypoxanthine arrow enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT) with PRPP arrow PPi to inosine monophosphate (IMP) arrow enzyme IMP dehydrogenase with H2O addition and NAD+ arrow NADH to XMP arrow enzyme GMP synthetase with Glutamine arrow Glutamate and ATP arrow AMP + PPi to GMP arrow enzyme GMP kinase with ATP arrow ADP to GDP arrow enzyme nucleoside diphosphate kinase with ATP arrow ADP to GTP arrow biopterin. IMP arrow enzyme adenylosuccinate synthetase with GTP arrow GDP, aspartate addition and loss of Pi to adenylosuccinate arrow enzyme adenylosuccinate lyase with loss of fumarate to AMP arrow enzyme adenylate kinase with ATP arrow ADP to ADP arrow enzyme nucleotide diphosphate kinase with GTP arrow GDP to ATP arrow S-adenosylmethionine, coenzyme A, NADH, FADH2. Adenine arrow enzyme adenine phosphoribosyltransferase with PRPP arrow Pi to AMP arrow enzyme AMP deaminase with loss of NH4+ to IMP. Uridine bidirectional arrow enzyme uridine phosphorylase with loss of uracil and Pi to ribose-1-P bidirectional arrow enzyme phosphomannomutase to Ribose-5-P arrow enzyme PRPP synthetase with ATP arrow AMP to PRPP. Guanine arrow enzyme HGPRT with PRPP arrow PPi to GMP arrow enzyme GMP reductase with NADPH arrow NADP+ and loss of NH4+ to IMP.