Despite annual availability of influenza vaccines in the United States, influenza is responsible for thousands of deaths and millions in medical costs every year. In part, this is due to vaccine hesitancy. Indeed, the average U.S. adult vaccination rate is 48%, which lags far behind the target rate of 70%. Although various demographic and psychosocial factors have been identified as correlates of influenza vaccine hesitancy, factors that promote infectious disease avoidance, such as disgust sensitivity, have been rarely examined. Using data from a year-long longitudinal study with a large national U.S. sample (Ns = 924), we will test whether disgust sensitivity is associated with previous flu vaccine uptake and influenza vaccine hesitancy, as well as prospectively predicts vaccine uptake during the 2020-2021 flu season. The findings from this project will expand our understanding of individual level factors associated with influenza vaccine hesitancy and uptake, as well as potentially highlight a psychological factor to be targeted in vaccine hesitancy interventions.