Background Universal health coverage (UHC) promotes access to necessary care and protects patients from financial hardship. UHC in general or universal pharmacare (with prescription medications) design features in particular may vary along the UHC axis cube, with dimensions being the population (who is covered?), products and services (what is covered?), and direct costs (proportion of costs covered?). Patterns in such design features may vary across contexts and may be useful in mapping the available evidence, including definitions, program characteristics, antecedents and outcomes or consequences of universal pharmacare. Identifying evidence about these factors can help inform policy development for the creation of new or strategically expanded universal pharmacare programs. Objective Our objective is to identify and conceptually map design features and the available evidence about the antecedents, program design features and consequences of universal pharmacare. Methods We will conduct a scoping review using the following key steps: 1) conducting searches to identify potentially relevant literature; 2) applying selection criteria; 3) mapping literature according to conceptual areas of interest; and 4) summarizing results. Each included document will be categorized according to document characteristics, antecedents (based on political- and health-system features), program design features (based on the axes of the UHC cube) and consequences of universal pharmacare (based on the quadruple aim metrics). This will be accompanied by a high-level synthesis of the key findings in relation to the key areas of UHC cube. Discussion The evidence generated from the scoping review will provide insight from the literature about antecedents, program design features, and consequences related to UHC with a focus on universal pharmacare. Given the importance of creating new or strategically expanding existing universal pharmacare models, the findings will be important for informing policy development in many countries.