The novel coronavirus disease 2019 (COVID-19) pneumonia pandemic, caused by the pathogenic severe acute respiratory syndrome-2 (SARS-CoV-2) virus, is spreading worldwide at an exponential rate. Pregnant women are more vulnerable to COVID-19 infection due to the physiological changes in the respiratory and immune system. This systematic review aims to assess the clinical characteristics, treatment and underlying complications of Coronavirus Disease 2019 (COVID-19) in pregnant women. Design Plan Study type Meta-Analysis - A systematic review of published studies.
Blinding No blinding is involved in this study. Is there any additional blinding in this study? There is no medical intervention being addressed in the study. We will collect publish data only Study design Literature searches will be conducted on PubMed, MEDLINE and Google scholar electronic databases. The search terms will be used include “Coronavirus Disease 2019” AND “Pregnancy” AND different country names listed in the World published in the period from 08 December 2019 through 15th April 2020. Additional searches will be conducted using reference lists of studies and review articles for selection of relevant articles. Main outcome(s) The clinical findings are going to be analysed on pregnant women diagnosed with SARS-CoV-2. Pneumonia, fever, cough, myalgia, dyspnea, shortness of breath, sore throat, diarrhoea, fatigue, headache and anemia are going to be included in clinical alterations. Measures of effect Percentages and frequency of the main clinical symptoms. Data extraction The titles of the studies resulted from the database searches will be screened initially and relevant papers will be selected. Then the abstracts and full texts will be reviewed according to the inclusion criteria for final selection. The titles, abstracts and full-text articles will be reviewed independently by three researchers (BS, vanTE, and IJBN). Extracted data will include authors, origin of studies, source population, study setting and period, inclusion/exclusion criteria, data sources and measurement, sample size, age distribution, maternal age, gestational age, vertical transmission, maternal characteristics, delivery characteristics, presenting sign & symptoms, ct scan report, treatment, maternal comorbidities, maternal outcome, and neonatal outcome.