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PubMed Central is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM).


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This article is from International Journal of Molecular Sciences , volume 15 . Abstract Acetylcholinesterase (AChE) inhibitors are widely used for the symptomatic treatment of Alzheimer’s disease and other dementias. More recent use is for myasthenia gravis. Many of these inhibitors interact with the second known cholinesterase, butyrylcholinesterase (BChE). Further, evidence shows that acetylcholine plays a role in suppression of cytokine release through a “cholinergic anti-inflammatory...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100123
PubMed Central
by Foote, Christopher
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This article is from BMC Research Notes , volume 7 . Abstract Contributing reviewers: The editors of BMC Research Notes would like to thank all of our reviewers who have contributed to the journal in volume 6 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895785
PubMed Central
by Rice, Catherine M
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This article is from BMC Genomics , volume 14 . Abstract Contributing reviewers: The editors of BMC Genomics would like to thank all our reviewers who have contributed to the journal in volume 13 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642022
PubMed Central
by Nagaraj, Anil Kumar Mysore
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This article is from Indian Journal of Psychiatry , volume 55 . Abstract Sex is a mysterious phenomenon, which has puzzled even great sages. Human beings have researched and mastered the biology of sex. But that is not all. Sex needs to be understood from the spiritual perspective too. The vision of Osho is an enlightening experience in this regard. Out of the thousands of lectures, five lectures on sex made Osho most notorious. Born into a Jain family of Madhya Pradesh, Rajneesh, who later...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705694
PubMed Central
by Pachai, Matthew V.; Sekuler, Allison B.; Bennett, Patrick J.
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This article is from Frontiers in Psychology , volume 4 . Abstract We measured thresholds in a 1-of-10 face identification task in which stimuli were embedded in orientation-filtered Gaussian noise. For upright faces, the threshold elevation produced by the masking noise varied as a function of noise orientation: significantly greater masking was obtained with horizontal noise than with vertical noise. However, the orientation selectivity of masking was significantly less with inverted faces....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580391
PubMed Central
by Solera, Dafne
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This article is from BMC Cancer , volume 14 . Abstract Contributing reviewers: The editors of BMC Cancer would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909450
PubMed Central
by Rasala, Beth A.; Chao, Syh-Shiuan; Pier, Matthew; Barrera, Daniel J.; Mayfield, Stephen P.
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This article is from PLoS ONE , volume 9 . Abstract Transgenic microalgae have the potential to impact many diverse biotechnological industries including energy, human and animal nutrition, pharmaceuticals, health and beauty, and specialty chemicals. However, major obstacles to sophisticated genetic and metabolic engineering in algae have been the lack of well-characterized transformation vectors to direct engineered gene products to specific subcellular locations, and the inability to robustly...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978050
PubMed Central
by Roncero, Carlos; Vega, Pablo; Martinez-Raga, Jose; Barral, Carmen; Basurte-Villamor, Ignacio; Rodriguez-Cintas, Laia; Mesias, Beatriz; Grau-Lopez, Lara; Casas, Miguel; Szerman, Nestor
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This article is from International Journal of Mental Health Systems , volume 8 . Abstract Background: Since provision of integrated services for patients with dual pathology or dual disorders (coexistence of an addictive disorder and other psychiatric disorders) constitutes an important challenge, this study compared the perceptions of health-care professionals with the existing, current state of specific resources for patients with dual pathology in Spain. Methods: Epidemiological,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158069
PubMed Central
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This article is from BMJ Open , volume 4 . Abstract Objectives: To test the effects of a school-based prevention programme on students’ smoking-related behaviour, attitudes and knowledge 6 months after implementation over 2 school-years has ended. Design: Two-arm prospective cluster randomised controlled trial with a follow-up survey 6 months after end of programme implementation, that is, 26 months after baseline. Setting: 45 public secondary schools from four federal states in Germany...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902526
PubMed Central
by Sands, Timothy R
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This article is from BMC Systems Biology , volume 8 . Abstract Contributing reviewers: The editors of BMC Systems Biology would like to thank all our reviewers who have contributed to the journal in Volume 7 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914848
PubMed Central
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This article is from Annals of The Royal College of Surgeons of England , volume 94 . Abstract INTRODUCTION: The preliminary results of a pyrocarbon interpositional radiocarpal implant in a small cohort of patients were reviewed. As it is currently only a limited release product, we describe to potential users early complications and negative outcomes. METHODS: Patients were assessed using pain levels, ranges of motion, grip strength, type of and time to return to work as well as pre-operative...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954246
PubMed Central
by Sherrington, David
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This article is from Philosophical transactions. Series A, Mathematical, physical, and engineering sciences , volume 368 . Abstract This paper is concerned with complex macroscopic behaviour arising in many-body systems through the combinations of competitive interactions and disorder, even with simple ingredients at the microscopic level. It attempts to indicate and illustrate the richness that has arisen, in conceptual understanding, in methodology and in application, across a large range of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263799
PubMed Central
by Harris, Philippa K
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This article is from BMC Microbiology , volume 13 . Abstract Contributing reviewers: The editors of BMC Microbiology would like to thank all our reviewers who have contributed to the journal in Volume 12 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576289
PubMed Central
by Harold, Simon
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This article is from BMC Plant Biology , volume 14 . Abstract Contributing reviewers: The editors of BMC Plant Biology would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897928
PubMed Central
by Rice, Catherine M
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This article is from BMC Bioinformatics , volume 14 . Abstract Contributing reviewers: The editors of BMC Bioinformatics would like to thank all our reviewers who have contributed to the journal in volume 13 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622621
PubMed Central
by Chae, Hyeseon; Min, Kyungdoo; Youn, kanwoo; Park, Jinwoo; Kim, Kyungran; Kim, Hyocher; Lee, Kyungsuk
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This article is from Annals of Occupational and Environmental Medicine , volume 26 . Abstract Objectives: This study estimated the rate of agricultural injury using a nationwide survey and identified factors associated with these injuries. Methods: The first Korean Farmers’ Occupational Disease and Injury Survey (KFODIS) was conducted by the Rural Development Administration in 2009. Data from 9,630 adults were collected through a household survey about agricultural injuries suffered in 2008....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012551
PubMed Central
by Harold, Simon
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This article is from BMC Plant Biology , volume 13 . Abstract Contributing reviewers: The editors of BMC Plant Biology would like to thank all of our reviewers who have contributed to the journal in Volume 12 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576327
PubMed Central
by Huang, Yan; Lu, Yi; Zhang, Lei; Yan, Jia; Jiang, Jue; Jiang, Hong
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This article is from International Journal of Molecular Sciences , volume 15 . Abstract Recent studies have shown that dexmedetomidine exerts an anti-inflammatory effect by reducing serum levels of inflammatory factors, however, the up-stream mechanism is still unknown. The transcription factor NF-κB enters the nucleus and promotes the transcription of its target genes, including those encoding the pro-inflammatory cytokines IL-6 and TNF-α. In this study, we established a rat model that...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975383
PubMed Central
by Morawska, Magdalena
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This article is from BMC Gastroenterology , volume 14 . Abstract Contributing reviewers: The editors of BMC Gastroenterology would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898228
PubMed Central
by Lu, Kai-hua; Li, Wei; Liu, Xiang-hua; Sun, Ming; Zhang, Mei-ling; Wu, Wei-qin; Xie, Wei-ping; Hou, Ya-yi
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This article is from BMC Cancer , volume 13 . Abstract Background: Long non-coding RNAs play an important role in tumorigenesis, hence, identification of cancer-associated lncRNAs and investigation of their biological functions and molecular mechanisms are important for understanding the development and progression of cancer. Recently, the downregulation of lncRNA MEG3 has been observed in various human cancers. However, its role in non-small cell lung cancer (NSCLC) is unknown. The aim of this...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851462
PubMed Central
by Hinrichsen, Inga; Ernst, Benjamin Philipp; Nuber, Franziska; Passmann, Sandra; Schafer, Dieter; Steinke, Verena; Friedrichs, Nicolaus; Plotz, Guido; Zeuzem, Stefan; Brieger, Angela
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This article is from Molecular Cancer , volume 13 . Abstract Introduction: Defects in the DNA mismatch repair (MMR) protein MLH1 are frequently observed in sporadic and hereditary colorectal cancers (CRC). Affected tumors generate much less metastatic potential than the MLH1 proficient forms. Although MLH1 has been shown to be not only involved in postreplicative MMR but also in several MMR independent processes like cytoskeletal organization, the connection between MLH1 and metastasis remains...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904401
PubMed Central
by Lossius, Hans Morten; S?reide, Kjetil; Bache, Kristi G
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This article is from Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , volume 22 . Abstract Contributing reviewers: The Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine—which received its first Impact Factor in 2013—is extremely grateful for the time, hard work and support of its highly-qualified peer reviewers. The editors of the Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, the Norwegian Air Ambulance Foundation and BioMed...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973829
PubMed Central
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This article is from Iranian Journal of Psychiatry and Behavioral Sciences , volume 6 . Abstract Objective: Approximately 66-80%of graduate students experience statistics anxiety and some researchers propose that many students identify statistics courses as the most anxiety-inducing courses in their academic curriculums. As such, it is likely that statistics anxiety is, in part, responsible for many students delaying enrollment in these courses for as long as possible. This paper proposes a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939948
PubMed Central
by Koszytkowska-Stawinska, Mariola; Buchowicz, Wlodzimierz
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This article is from Beilstein Journal of Organic Chemistry , volume 10 . Abstract This review covers sixty original publications dealing with the application of multicomponent reactions (MCRs) in the synthesis of novel nucleoside analogs. The reported approaches were employed for modifications of the parent nucleoside core or for de novo construction of a nucleoside scaffold from non-nucleoside substrates. The cited references are grouped according to the usually recognized types of the MCRs....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142899
PubMed Central
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This article is from PLoS ONE , volume 8 . Abstract Heparan sulfate Proteoglycans (HSPG) are ubiquitous molecules with indispensable functions in various biological processes. Glypicans are a family of HSPG’s, characterized by a Gpi-anchor which directs them to the cell surface and/or extracellular matrix where they regulate growth factor signaling during development and disease. We report the identification and expression pattern of glypican genes from zebrafish. The zebrafish genome...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828384
PubMed Central
by Taillebois, Emiliane; Beloula, Abdelhamid; Quinchard, Sophie; Jaubert-Possamai, Stephanie; Daguin, Antoine; Servent, Denis; Tagu, Denis; Thany, Steeve H.; Tricoire-Leignel, Helene
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This article is from PLoS ONE , volume 9 . Abstract Neonicotinoid insecticides act on nicotinic acetylcholine receptor and are particularly effective against sucking pests. They are widely used in crops protection to fight against aphids, which cause severe damage. In the present study we evaluated the susceptibility of the pea aphid Acyrthosiphon pisum to the commonly used neonicotinoid insecticides imidacloprid (IMI), thiamethoxam (TMX) and clothianidin (CLT). Binding studies on aphid...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011867
PubMed Central
by Jahanbakhsh, Rouzbeh; Atyabi, Fatemeh; Shanehsazzadeh, Saeed; Sobhani, Zahra; Adeli, Mohsen; Dinarvand, Rassoul
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This article is from DARU Journal of Pharmaceutical Sciences , volume 21 . Abstract Background and purpose of the study: Carbon nanotubes (CNTs) are emerging drug and imaging carrier systems which show significant versatility. One of the extraordinary characteristics of CNTs as Magnetic Resonance Imaging (MRI) contrasting agent is the extremely large proton relaxivities when loaded with gadolinium ion (Gdn3+) clusters. Methods: In this study equated Gdn3+ clusters were loaded in the sidewall...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716729
PubMed Central
by Shipley, Tim
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This article is from BMC Neurology , volume 14 . Abstract Contributing reviewers: The editors of BMC Neurology would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973960
PubMed Central
by Pafitis, Natalie
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This article is from BMC Public Health , volume 13 . Abstract Contributing reviewers: The editors of BMC Public Health would like to thank all our reviewers who have contributed to the journal in 2012.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751667
PubMed Central
by Villaverde, Antonio
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This article is from Microbial Cell Factories , volume 12 . Abstract Contributing reviewers: The Editors of Microbial Cell Factories would like to thank all our Reviewers who have contributed to the journal in Volume 11 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576239
PubMed Central
by Medina-Ortega, Karla J.; Walker, G. P.
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This article is from Journal of Experimental Botany , volume 64 . Abstract To protect against loss of photo-assimilate-rich phloem sap, plants have evolved several mechanisms to plug phloem sieve tubes in response to damage. In many Fabaceae, each sieve element contains a discrete proteinaceous body called a forisome, which, in response to damage, rapidly transforms from a condensed configuration that does not impede the flow of sap to a dispersed configuration that plugs the sieve element....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871815
PubMed Central
by Foote, Christopher
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This article is from BMC Evolutionary Biology , volume 14 . Abstract Contributing reviewers: The editors of BMC Evolutionary Biology would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905664
PubMed Central
by Cooper, Khushnuma; Shah, Viru; Sapre, Nupur; Sharma, Ekta; Mistry, Chetna; Viswanathan, Chandra
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This article is from International Journal of Hematology-Oncology and Stem Cell Research , volume 7 . Abstract Background: Umbilical cord tissue is a very rich source of mesenchymal stem cells. Instead of discarding this source we are banking the tissue along with cord blood for possible future cell based applications. The cord tissue needs to be transported and stored properly in order for it to be good enough for cell isolation at a later date. In this paper we have carried out a validation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915426
PubMed Central
by Chen, Dengyu; Zhang, Yunxia; Wang, Jing; Chen, Junsong; Yang, Cuiping; Cai, Kai; Wang, Xiaoying; Shi, Fangfang; Dou, Jun
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This article is from Journal of Ovarian Research , volume 6 . Abstract Background: Cancer stem cells (CSCs) are believed to be ‘seed cell’ in cancer recurrence and metastasis. MicroRNAs (miRNAs) can play an important role in the progression of primary tumor towards metastasis by regulating the epithelial-mesenchymal transition (EMT). The goal of this study was to investigate the effect of miRNA-200c overexpression on the EMT, tumorigenicity and metastasis of epithelial ovarian cancer (EOC)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729499
PubMed Central
by Min, Jing-jing; Huo, Xin-long; Xiang, ling-yun; Qin, Yan-qing; Chai, Ke-qin; Wu, Bin; Jin, Lu; Wang, Xiao-tong
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This article is from Scientific Reports , volume 4 . Abstract Cognitive impairment is a common finding in patients with chronic obstructive pulmonary disease (COPD), but little attention has been focused on therapeutic intervention for this complication. Chronic intermittent hypoxia hypercapnia (CIHH) exposure is considered to be responsible for the pathogenesis of COPD. Dl-3n-Butylphthalide (NBP), extracted from Apium graveolens Linn, has displayed a broad spectrum of neuroprotective...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080197
PubMed Central
by Noland, Gregory S; Graves, Patricia M; Sallau, Adamu; Eigege, Abel; Emukah, Emmanuel; Patterson, Amy E; Ajiji, Joseph; Okorofor, Iheanyichi; Oji, Oji Uka; Umar, Mary; Alphonsus, Kal; Damen, James; Ngondi, Jeremiah; Ozaki, Masayo; Cromwell, Elizabeth; Obiezu, Josephine; Eneiramo, Solomon; Okoro, Chinyere; McClintic-Doyle, Renn; Oresanya, Olusola; Miri, Emmanuel; Emerson, Paul M; Richards, Frank O
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This article is from BMC Infectious Diseases , volume 14 . Abstract Background: Nigeria suffers the world’s largest malaria burden, with approximately 51 million cases and 207,000 deaths annually. As part of the country’s aim to reduce by 50% malaria-related morbidity and mortality by 2013, it embarked on mass distribution of free long-lasting insecticidal nets (LLINs). Methods: Prior to net distribution campaigns in Abia and Plateau States, Nigeria, a modified malaria indicator survey was...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994282
PubMed Central
by Kong, Ya-Jie; Yuan, Zhuang-Dong
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 67 . Abstract In the title compound, [Cu(C2H3O3)(C12H8N2)2]NO3, the CuII atom is coordinated by two phenanthroline (phen) ligands and one carboxyl-O atom of a hy­droxy­acetate anion in a distorted square-pyramidal geometry. The hy­droxy group of the hy­droxy­acetate ligand links with the counter NO3− anion via a pair of bifurcated O—H⋯O hydrogen bonds. The centroid–centroid distance of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089357
PubMed Central
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This article is from ZooKeys . Abstract AbstractThe genus Balera Young is reported for first time to Argentina and a new species is described, Balera floriparasp. n. Detailed morphological descriptions and illustrations of the new species and a key to males of known species are provided. Habralebra amoena is also recorded for the first time from Argentina.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837395
PubMed Central
by Pefura-Yone, Eric Walter; Kengne, Andre Pascal; Kuaban, Christopher
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This article is from BMC Infectious Diseases , volume 14 . Abstract Background: We investigated the determinants of sputum culture non-conversion following intensive phase of treatment, and assessed the effects on the outcome among patients treated for a first episode of smear positive tuberculosis (TB). Methods: This was a prospective cohort study spanning October 2009 to May 2012, among patients treated for a first episode of smear positive pulmonary tuberculosis in the Chest service of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984706
PubMed Central
by Stieglmeier, Michaela; Klingl, Andreas; Alves, Ricardo J. E.; Rittmann, Simon K.-M. R.; Melcher, Michael; Leisch, Nikolaus; Schleper, Christa
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This article is from International Journal of Systematic and Evolutionary Microbiology , volume 64 . Abstract A mesophilic, neutrophilic and aerobic, ammonia-oxidizing archaeon, strain EN76T, was isolated from garden soil in Vienna (Austria). Cells were irregular cocci with a diameter of 0.6–0.9 µm and possessed archaella and archaeal pili as cell appendages. Electron microscopy also indicated clearly discernible areas of high and low electron density, as well as tubule-like structures....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129164
PubMed Central
by Otterbein, Leo E
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This article is from Medical Gas Research , volume 3 . Abstract The articles contained in this review series exemplify the diverse applications and succinct biological relevance of this simple gas. Articles summarizing the important effects of carbon monoxide in preventing the rejection of an organ, in its neuroprotective properties in piglets, regulation of mycobacterial growth, in its anti-inflammatory effects in the gut and in its use in new and innovative modalities and avenues by which to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610149
PubMed Central
by Majithia, Deesha A
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This article is from BMC Neuroscience , volume 14 . Abstract Contributing reviewers: The editors of BMC Neuroscience would like to thank all our reviewers who have contributed to the journal in Volume 13 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626905
PubMed Central
by Giannella-Neto, Daniel; de Brito Gomes, Marilia; Abel, Lucy
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This article is from Diabetology & Metabolic Syndrome , volume 5 . Abstract Contributing reviewers: The Editors of Diabetology and Metabolic Syndrome would like to thank all reviewers, both external and Editorial Board Members, who have contributed to the journal since its inception, and whose valuable support continues to be essential to the success of the journal.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605392
PubMed Central
by Tu, Qichao; He, Zhili; Zhou, Jizhong
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This article is from Nucleic Acids Research , volume 42 . Abstract Shotgun metagenome sequencing has become a fast, cheap and high-throughput technology for characterizing microbial communities in complex environments and human body sites. However, accurate identification of microorganisms at the strain/species level remains extremely challenging. We present a novel k-mer-based approach, termed GSMer, that identifies genome-specific markers (GSMs) from currently sequenced microbial genomes,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005670
PubMed Central
by Horn, Fabian; Schroeckh, Volker; Netzker, Tina; Guthke, Reinhard; Brakhage, Axel A.; Linde, Jorg
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This article is from Genome Announcements , volume 2 . Abstract Streptomyces iranensis HM 35 has been shown to exhibit 72.7% DNA-DNA similarity to the important drug rapamycin (sirolimus)-producing Streptomyces rapamycinicus NRRL5491. Here, we report the genome sequence of HM 35, which represents a partially overlapping repertoire of secondary metabolite gene clusters with S. rapamycinicus, including the gene cluster for rapamycin biosynthesis.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102860
PubMed Central
by Wang, B.; Gao, C.; Chen, W. L.; Miao, J.; Zhu, X.; Bai, Y.; Zhang, J. W.; Feng, Y. Y.; Li, T. C.; Wang, L. J.
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This article is from Scientific Reports , volume 2 . Abstract The synchronisation of time and frequency between remote locations is crucial for many important applications. Conventional time and frequency dissemination often makes use of satellite links. Recently, the communication fibre network has become an attractive option for long-distance time and frequency dissemination. Here, we demonstrate accurate frequency transfer and time synchronisation via an 80 km fibre link between Tsinghua...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412274
This article is from Genome Biology and Evolution , volume 5 . Abstract The question of Jewish ancestry has been the subject of controversy for over two centuries and has yet to be resolved. The “Rhineland hypothesis” depicts Eastern European Jews as a “population isolate” that emerged from a small group of German Jews who migrated eastward and expanded rapidly. Alternatively, the “Khazarian hypothesis” suggests that Eastern European Jews descended from the Khazars, an amalgam of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595026
PubMed Central
by Zhang, Nan-nan; Park, Dong Ki; Park, Hye-Jin
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This article is from BMC Complementary and Alternative Medicine , volume 13 . Abstract Background: Thuja orientalis has been traditionally used to treat patients who suffer from baldness and hair loss in East Asia. The present study sought to investigate the hair growth-promoting activity of T. orientalis hot water extract and the underlying mechanism of action. Methods: After T. orientalis extract was topically applied to the shaved dorsal skin of telogenic C57BL/6 N mice, the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637267
PubMed Central
by Serra, Raffaele; Gallelli, Luca; Conti, Angela; De Caridi, Giovanni; Massara, Mafalda; Spinelli, Francesco; Buffone, Gianluca; Calio, Francesco Giuseppe; Amato, Bruno; Ceglia, Simona; Spaziano, Giuseppe; Scaramuzzino, Luca; Ferrarese, Alessia Giovanna; Grande, Raffaele; de Franciscis, Stefano
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This article is from Drug Design, Development and Therapy , volume 8 . Abstract Background: Mixed venous and arterial ulcers account for approximately 15%–30% of all venous leg ulcerations. Several studies have shown that matrix metalloproteinases (MMPs) and neutrophil gelatinase-associated lipocalin (NGAL) play a central role in the pathophysiology of venous and arterial diseases. Some studies have shown the efficacy of glycosaminoglycans, such as sulodexide (SDX), in treating patients with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026398
PubMed Central
by Quinones, Philip Andrew; Kirchberger, Inge; Heier, Margit; Kuch, Bernhard; Trentinaglia, Ines; Mielck, Andreas; Peters, Annette; von Scheidt, Wolfgang; Meisinger, Christa
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This article is from BMC Public Health , volume 14 . Abstract Background: Reduction of long term mortality by marital status is well established in general populations. However, effects have been shown to change over time and differ considerably by cause of death. This study examined the effects of marital status on long term mortality after the first acute myocardial infarction. Methods: Data were retrieved from the population-based MONICA (Monitoring trends and determinants on cardiovascular...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937149
PubMed Central
by de Lores Arnaiz, Georgina Rodriguez; Ordieres, Maria Graciela Lopez
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This article is from International Journal of Biomedical Science : IJBS , volume 10 . Abstract Na+/K+ pump or sodium- and potassium-activated adenosine 5’-triphosphatase (Na+, K+-ATPase), its enzymatic version, is a crucial protein responsible for the electrochemical gradient across the cell membranes. It is an ion transporter, which in addition to exchange cations, is the ligand for cardenolides. This enzyme regulates the entry of K+ with the exit of Na+ from cells, being the responsible for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092085
PubMed Central
by Hobara, Hiroaki; Kobayashi, Yoshiyuki; Ueda, Tomoya; Mochimaru, Masaaki
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This article is from Journal of Foot and Ankle Research , volume 7 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101450
PubMed Central
by Al-Atrushi, Hazha H; Al-Tawil, Namir G; Shabila, Nazar P; Al-Hadithi, Tariq S
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This article is from BMC Women's Health , volume 13 . Abstract Background: Violence against women is a worldwide problem and serious human rights abuse that occurs among all social, cultural, economic and religious groups. There is a paucity of research on intimate partner violence against women in Iraq, particularly in the Kurdistan region. This study assessed the prevalence of emotional, physical and sexual intimate partner violence against women and the impact of physical violence in Erbil,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852841
PubMed Central
by Hoyo-Becerra, Carolina; Huebener, Anastasia; Trippler, Martin; Lutterbeck, Melanie; Liu, Zijian J.; Truebner, Kurt; Bajanowski, Thomas; Gerken, Guido; Hermann, Dirk M.; Schlaak, Joerg F.
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This article is from PLoS ONE , volume 8 . Abstract We have previously identified 15 genes that are associated with the development of severe depressive side effects during the standard therapy with interferon alpha and ribavirin in the peripheral blood of hepatitis C virus infected patients. An enhanced expression of these genes was also found in the blood of psychiatric patients suffering severe depressive episode. Herein, we demonstrate that the same depression-related interferon-inducible...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877033
PubMed Central
by Bernasconi, Sergio; Caffarelli, Carlo; Santamaria, Francesca
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This article is from Italian Journal of Pediatrics , volume 40 . Abstract Contributing reviewers: The editors of Italian Journal of Pediatrics would like to thank all our reviewers who have contributed to the journal in Volume 39 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923234
PubMed Central
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This article is from The EMBO Journal , volume 33 . Abstract The extrinsic apoptosis pathway is initiated by binding of death ligands to death receptors resulting in the formation of the death-inducing signaling complex (DISC). Activation of procaspase-8 within the DISC and its release from the signaling complex is required for processing executor caspases and commiting cell death. Here, we report that the atypical cadherin FAT1 interacts with caspase-8 preventing the association of caspase-8...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983683
PubMed Central
by Predel, Hans-Georg; Giannetti, Bruno; Pabst, Helmut; Schaefer, Axel; Hug, Agnes M; Burnett, Ian
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This article is from BMC Musculoskeletal Disorders , volume 14 . Abstract Background: Neck pain (NP) is a common musculoskeletal disorder in primary care that frequently causes discomfort. Non-steroidal anti-inflammatory drugs (NSAIDs) may be used to reduce neck pain and associated inflammation and facilitate earlier recovery. Topical diclofenac diethylamine (DDEA) 1.16% gel is clinically proven to be effective and well tolerated in acute and chronic musculoskeletal conditions, but until now no...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847223
PubMed Central
by Gharavi, MJ; Nobakht, M; Khademvatan, S; Fani, F; Bakhshayesh, M; Roozbehani, M
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This article is from Iranian Journal of Public Health , volume 40 . Abstract Background: The aim of the present study was to investigate the immunomodulation effects of aqueous garlic extract (AGE) in the cultured macrophages infected by Leishmania major. Methods:: After J774 macrophages proliferation in RPMI1640 and incubation with Leishmania for 72 hours, AGE was added in doses of 9.25, 18.5, 37, 74 and 148 mg/ml for 18, 24 and 48 hours and cell culture supernatants were harvested. The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481747
PubMed Central
by Lionetti, Lilla; Mollica, Maria Pina; Donizzetti, Immacolata; Gifuni, Giorgio; Sica, Raffaella; Pignalosa, Angelica; Cavaliere, Gina; Gaita, Marcello; De Filippo, Chiara; Zorzano, Antonio; Putti, Rosalba
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This article is from PLoS ONE , volume 9 . Abstract Background: Mitochondria are dynamic organelles that frequently undergo fission and fusion processes, and imbalances in these processes may be involved in obesity and insulin resistance. Aims: The present work had the following aims: (a) to evaluate whether the mitochondrial dysfunction present in the hepatic steatosis induced by a high-fat diet is associated with changes in mitochondrial dynamics and morphology; (b) to evaluate whether...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963938
PubMed Central
by De Groot, Anne S; Einck, Leo; Moise, Leonard; Chambers, Michael; Ballantyne, John; Malone, Robert W; Ardito, Matthew; Martin, William
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This article is from Human Vaccines & Immunotherapeutics , volume 9 . Abstract The integrated US Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) has made great strides in strategic preparedness and response capabilities. There have been numerous advances in planning, biothreat countermeasure development, licensure, manufacturing, stockpiling and deployment. Increased biodefense surveillance capability has dramatically improved, while new tools and increased awareness...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906351
PubMed Central
by Meng, Qing-Wen; Zhang, Zai-Ping; Wang, Wei; Tian, Jin; Xiao, Zhi-Guang
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This article is from Virology Journal , volume 8 . Abstract Background: Avian leukosis virus (ALV) is a major infectious disease that impacts the poultry industry worldwide. Despite intensive efforts, no effective vaccine has been developed against ALV because of mutations that lead to resistant forms. Therefore, there is a dire need to develop antiviral agents for the treatment of ALV infections and RNA interference (RNAi) is considered an effective antiviral strategy. Results: In this study,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296551
PubMed Central
by Carbonell-Baeza, Ana; Ruiz, Jonatan R; Aparicio, Virginia A; Ortega, Francisco B; Munguia-Izquierdo, Diego; Alvarez-Gallardo, Inmaculada C; Segura-Jimenez, Victor; Camiletti-Moiron, Daniel; Romero, Alejandro; Estevez-Lopez, Fernando; Samos, Blanca; Casimiro, Antonio J; Sierra, Angela; Latorre, Pedro A; Pulido-Martos, Manuel; Femia, Pedro; Perez-Lopez, Isaac J; Chillon, Palma; Girela-Rejon, Maria J; Tercedor, Pablo; Lucia, Alejandro; Delgado-Fernandez, Manuel
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This article is from BMC Musculoskeletal Disorders , volume 13 . Abstract Background: The al-Andalus physical activity intervention study is a randomised control trial to investigate the effectiveness of a land- and water-based exercise intervention for reducing the overall impact of fibromyalgia (primary outcome), and for improving tenderness and pain-related measures, body composition, functional capacity, physical activity and sedentary behaviour, fatigue, sleep quality, health-related...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350451
This article is from PLoS ONE , volume 9 . Abstract The chemokine domain of fractalkine (FKN-CD) binds to the classical RGD-binding site of αvβ3 and that the resulting ternary complex formation (integrin-FKN-CX3CR1) is critical for CX3CR1 signaling and FKN-induced integrin activation. However, only certain cell types express CX3CR1. Here we studied if FKN-CD can activate integrins in the absence of CX3CR1. We describe that WT FKN-CD activated recombinant soluble αvβ3 in cell-free...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008574
PubMed Central
by Wuestenberg, Andrea; Kah, Janine; Singethan, Katrin; Sirma, Huseyin; Keller, Amelie Dorothea; Rosal, Sergio Rene Perez; Schrader, Jorg; Loscher, Christine; Volz, Tassilo; Bartenschlager, Ralf; Lohmann, Volker; Protzer, Ulrike; Dandri, Maura; Lohse, Ansgar W.; Tiegs, Gisa; Sass, Gabriele
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This article is from PLoS ONE , volume 9 . Abstract Background & Aims: HMG-CoA-reductase-inhibitors (statins) have been shown to interfere with HCV replication in vitro. We investigated the mechanism, requirements and contribution of heme oxygenase-1(HO-1)-induction by statins to interference with HCV replication. Methods: HO-1-induction by fluva-, simva-, rosuva-, atorva- or pravastatin was correlated to HCV replication, using non-infectious replicon systems as well as the infectious cell...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011762
PubMed Central
by Carlisle, Eli; Yarnes, Chris; Toney, Michael D.; Bloom, Arnold J.
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This article is from Frontiers in Plant Science , volume 5 . Abstract Stable 15N isotopes have been used to examine movement of nitrogen (N) through various pools of the global N cycle. A central reaction in the cycle involves the reduction of nitrate (NO−3) to nitrite (NO−2) catalyzed by nitrate reductase (NR). Discrimination against 15N by NR is a major determinant of isotopic differences among N pools. Here, we measured in vitro15N discrimination by several NRs purified from plants,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078254
PubMed Central
by Ochi-ishi, Ryutaro; Nagata, Kenichiro; Inoue, Tomoyuki; Tozaki-Saitoh, Hidetoshi; Tsuda, Makoto; Inoue, Kazuhide
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This article is from Molecular Pain , volume 10 . Abstract Background: Paclitaxel is an effective chemotherapeutic agent widely used for the treatment of solid tumors. The major dose-limiting toxicity of paclitaxel is peripheral neuropathy. The mechanisms underlying the development and maintenance of paclitaxel-induced peripheral neuropathy are still unclear, and there are no currently established effective treatments. Accumulating evidence in models of neuropathic pain in which peripheral...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141668
PubMed Central
by Herrmann, Ken; Buck, Andreas K.; Schuster, Tibor; Abbrederis, Kathrin; Blumel, Christina; Santi, Ivan; Rudelius, Martina; Wester, Hans-Jurgen; Peschel, Christian; Schwaiger, Markus; Dechow, Tobias; Keller, Ulrich
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This article is from Oncotarget , volume 5 . Abstract Despite improved survival in the Rituximab (R) era, a considerable number of patients with diffuse large B-cell lymphoma (DLBCL) ultimately die from the disease. Functional imaging using [18F]fluorodeoxyglucose-PET is suggested for assessment of residual viable tumor very early during treatment but is compromised by non-specific tracer retention in inflammatory lesions. The PET tracer [18F]fluorodeoxythymidine (FLT) as surrogate marker of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147305
PubMed Central
by de Visser, Sam P.
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This article is from Frontiers in Chemistry , volume 1 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982559
This article is from Arthritis Research & Therapy , volume 16 . Abstract Introduction: Although neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the recalcitrant complications of the disease, its pathogenesis still remains unclear. Previous studies revealed that antibodies reactive with NMDA (N-methyl-D-aspartate) receptor NR2 (anti-NR2) are elevated in cerebrospinal fluid (CSF) of patients with diffuse psychiatric/neuropsychological syndromes (diffuse NPSLE), which is...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060173
PubMed Central
by Venturelli, Sascha; Sinnberg, Tobias W.; Berger, Alexander; Noor, Seema; Levesque, Mitchell Paul; Bocker, Alexander; Niessner, Heike; Lauer, Ulrich M.; Bitzer, Michael; Garbe, Claus; Busch, Christian
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This article is from Frontiers in Oncology , volume 4 . Abstract In recent years, increasing evidence has emerged demonstrating that high-dose ascorbate bears cytotoxic effects on cancer cells in vitro and in vivo, making ascorbate a pro-oxidative drug that catalyzes hydrogen peroxide production in tissues instead of acting as a radical scavenger. This anticancer effect of ascorbate is hypoxia-inducible factor-1α- and O2-dependent. However, whether the intracellular mechanisms governing this...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142417
PubMed Central
by Lantow, Margareta; Sivakumar, Ramya; Zeumer, Leilani; Wasserfall, Clive; Zheng, Ying-Yi; Atkinson, Mark A; Morel, Laurence
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This article is from Arthritis Research & Therapy , volume 15 . Abstract Introduction: An NZB-derived genetic locus (Sle2c2) that suppresses autoantibody production in a mouse model of induced systemic lupus erythematosus contains a polymorphism in the gene encoding the G-CSF receptor. This study was designed to test the hypothesis that the Sle2c2 suppression is associated with an impaired G-CSF receptor function that can be overcome by exogenous G-CSF. Methods: Leukocytes from B6.Sle2c2...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672747
PubMed Central
by Abubakar, Amina; Holding, Penny; Van Baar, Anneloes; Newton, Charles. R. J. C.; Van de Vijver, Fons. J. R.; Espy, Kimberly Andrews
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This article is from International Journal of Environmental Research and Public Health , volume 10 . Abstract The aim of the study was to investigate early executive functioning in young children from 6–35 months of age. The study involved 319 randomly selected children from the community, 17 HIV exposed but uninfected children and 31 HIV infected ARV-naive children. A variation of the A-not-B task was used. While there were no group differences in total correct, perseverative errors, nor...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799506
PubMed Central
by Moutinho, Catia; Martinez-Cardus, Anna; Santos, Cristina; Navarro-Perez, Valentin; Martinez-Balibrea, Eva; Musulen, Eva; Carmona, F. Javier; Sartore-Bianchi, Andrea; Cassingena, Andrea; Siena, Salvatore; Elez, Elena; Tabernero, Josep; Salazar, Ramon; Abad, Albert; Esteller, Manel
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This article is from JNCI Journal of the National Cancer Institute , volume 106 . Abstract Background: A major problem in cancer chemotherapy is the existence of primary resistance and/or the acquisition of secondary resistance. Many cellular defects contribute to chemoresistance, but epigenetic changes can also be a cause. Methods: A DNA methylation microarray was used to identify epigenetic differences in oxaliplatin-sensitive and -resistant colorectal cancer cells. The candidate gene SRBC...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906989
PubMed Central
by Szydelko, Tomasz; Lewandowski, Jaroslaw; Panek, Wojciech; Tupikowski, Krzysztof; Dembowski, Janusz; Zdrojowy, Romuald
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This article is from Central European Journal of Urology , volume 65 . Abstract Objectives: The objective of the study is to summarize the authors’ 10-year experience with laparoscopic adrenalectomy and to analyze the intra- and postoperative complications of the procedure. Material and methods: The records of 80 patients who had undergone laparoscopic adrenalectomy from January 2002 to January 2012 were reviewed retrospectively. There were 51 female and 29 male patients. The average age was...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921778
PubMed Central
by Ferreira, Valerie; Petry, Harald; Salmon, Florence
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This article is from Frontiers in Immunology , volume 5 . Abstract Alipogene tiparvovec (Glybera®) is an adeno-associated virus serotype 1 (AAV1)-based gene therapy that has been developed for the treatment of patients with lipoprotein lipase (LPL) deficiency. Alipogene tiparvovec contains the human LPL naturally occurring gene variant LPLS447X in a non-replicating viral vector based on AAV1. Such virus-derived vectors administered to humans elicit immune responses against the viral capsid...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939780