6
6.0
Feb 8, 2022
02/22
Feb 8, 2022
by
Valerio G Giacobelli, Kosuke Fujishima, Martin Lepšík, Vyacheslav Tretyachenko, Tereza Kadavá, Mikhail Makarov, Lucie Bednárová, Petr Novák, Klára Hlouchová
texts
eye 6
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RNA–peptide/protein interactions have been of utmost importance to life since its earliest forms, reaching even before the last universal common ancestor (LUCA). However, the ancient molecular mechanisms behind this key biological interaction remain enigmatic because extant RNA–protein interactions rely heavily on positively charged and aromatic amino acids that were absent (or heavily under-represented) in the early pre-LUCA evolutionary period. Here, an RNA-binding variant of the...
Topics: RNA–protein interaction, genetic code evolution, protein evolution, mRNA-display
59
59
Jul 22, 2021
07/21
Jul 22, 2021
texts
eye 59
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Caveat Emptor --- “let the buyer beware.” " ARPA-H will be tasked with building high-risk , high-reward capabilities (or platforms) to drive biomedical breakthroughs ."
Topics: ARPA-H, ARPA-E, DARPA, NIH, CDC, FDA, CMS, BARDA, ASPR, OMH, ACL, AHRQ, NSF, NIST, DOE, RADx, DNA,...
163
163
Dec 18, 2020
12/20
Dec 18, 2020
by
Moonlight
movies
eye 163
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Ms. Moonlight. The blue ray represents power, protection, faith, and strength. Whitney Hopler is a writer and editor who has covered faith since 1994. She is the author of the book "Wake Up to Wonder." The blue angel light ray represents power, protection, faith, courage, and strength. https://youtu.be/zNry-oK_K7s “The Blue Ray Beings are a group of empathic and ultra-sensitive souls like the Indigos who came from different ascended planets and realms of light to illuminate the...
Topics: Blue Ray, ultra-sensitive souls, Indigos, the genetic code of humanity, Lightworker, Shekinah,...
61
61
Aug 7, 2020
08/20
Aug 7, 2020
by
DCTV
movies
eye 61
favorite 0
comment 0
Produced by DCTV (DeKalb County Television) Channel 23, this PSA highlights the “Be The Match” campaign to raise awareness of the need for more minority stem cell donors. Additional information: For patients battling blood cancers like leukemia or lymphoma, or more than 70 life-threatening blood disorders including sickle cell, there is a cure through a blood stem cell transplant. The “Be The Match” Registry – the world’s largest listing of potential stem cell donors operated by the...
Topics: Georgia, DeKalb County, DeKalb County Television, DCTV, Government Access TV, Community Media, PEG,...
116
116
Aug 7, 2020
08/20
Aug 7, 2020
by
DCTV
movies
eye 116
favorite 0
comment 0
Produced by DCTV (DeKalb County Television) Channel 23, this PSA highlights the “Be The Match” campaign to raise awareness of the need for more minority stem cell donors. Additional information: For patients battling blood cancers like leukemia or lymphoma, or more than 70 life-threatening blood disorders including sickle cell, there is a cure through a blood stem cell transplant. The “Be The Match” Registry – the world’s largest listing of potential stem cell donors operated by the...
Topics: Georgia, DeKalb County, DeKalb County Television, DCTV, Government Access TV, Community Media, PEG,...
78
78
Aug 7, 2020
08/20
Aug 7, 2020
by
DCTV
movies
eye 78
favorite 0
comment 0
Produced by DCTV (DeKalb County Television) Channel 23, this PSA highlights the “Be The Match” campaign to raise awareness of the need for more minority stem cell donors. Additional information: For patients battling blood cancers like leukemia or lymphoma, or more than 70 life-threatening blood disorders including sickle cell, there is a cure through a blood stem cell transplant. The “Be The Match” Registry – the world’s largest listing of potential stem cell donors operated by the...
Topics: Georgia, DeKalb County, DeKalb County Television, DCTV, Government Access TV, Community Media, PEG,...
In Part One of our Making a Phenom mini-series, Neil deGrasse Tyson and co-hosts Gary O'Reilly and Chuck Nice explore sports genetics alongside investigative reporter and author David Epstein and Stuart Kim, PhD, Founder and CEO of AxGen.
Topics: Podcast, Episode, StarTalk Sports Edition, Science Podcast, Sports Podcast, Star talk, StarTalk,...
74
74
Dec 31, 2018
12/18
Dec 31, 2018
by
Brian K. Davis
texts
eye 74
favorite 0
comment 0
Transformation of the codon-anticodon interface from a purine ladder, resulting from self-recognition between adenosine base pairs, to a double helix, resulted from uridine replacement of anticcodon adenosine bases. This provided a mechanism for replacement of the purine ladder by the double helix
Topics: codon-anticodon interface, ladder transition, genetic code expansion
Cell-free protein synthesis has emerged as a powerful approach for expanding the range of genetically encoded chemistry into proteins. Unfortunately, efforts to site-specifically incorporate multiple non-canonical amino acids into proteins using crude extract-based cell-free systems have been limited by release factor 1 competition. Here we address this limitation by establishing a bacterial cell-free protein synthesis platform based on genomically recoded Escherichia coli lacking release...
Topics: DTIC Archive, Martin,Rey W, Northwestern University Evanston United States, synthetic biology,...
23
23
Oct 30, 2017
10/17
Oct 30, 2017
by
DEFCONConference
movies
eye 23
favorite 0
comment 0
Recent advances in genome editing have quickly turned ideas thought restricted to science fiction into reality such as custom synthetic organisms and designer babies. These technologies rely on the fidelity of the genetic code, which translates nucleotides into proteins. The underlying mechanism of translation is well understood where triplets of nucleotides, known as codons, are recognized by transfer RNAs with complementally nucleotide triplets. These transfer RNAs carry one of twenty amino...
Topics: Youtube, video, Science & Technology, DEF, CON, DEF CON 2017, DEF CON 25, DEF CON, DC25,...
4,927
4.9K
Mar 20, 2017
03/17
Mar 20, 2017
by
Capital Public Radio, Inc.
audio
eye 4,927
favorite 0
comment 0
Political Junkie: Neil Gorsuch, FBI Investigations and Wire-Tapping Political Junkie Ken Rudin discusses the hearings happening Monday involving Neil Gorsuch's Supreme Court nomination, accusations of Obama wire-tapping Trump Tower and the White House, and the possible influence of Russian interfering with elections. Zip Code Vs. Genetic Code: Which Matters More For Life Expectancy? Dr. Anthony Iton shares his latest research on life expectancy in the Central Valley and what's being done to...
Topics: KXJZ, Insight, Sacramento, public, radio, Capital Public Radio, CSU Sacramento, Ken Rudin, The...
Ebola virus (EBOV) is a single-stranded negative-sense RNA virus belonging to the Filoviridae family. The leader and trailer non-coding regions of the EBOV genome likely regulate its transcription, replication and progeny genome packaging. We investigated the cis-acting RNA signals involved in RNA-RNA and RNA-protein interactions that regulate replication of eGFP-encoding EBOV minigenomic RNA and identified heat shock cognate protein family A (HSC70) member 8 (HSPA8) as an EBOV...
Topics: DTIC Archive, Radoshitzky, Sheli, USAMRIID Frederick United States, Ebola virus, Genetic...
The emphasis of this project is to procure essential equipments required to establish new capacity to conduct research and education in bioenergy and environmental biotechnology at West Virginia State University (WVSU). Bioenergy and environmental biotechnology research and education affected by the acquisition of this new equipment and instrumentations includes development of new technology to produce biofuels, bioremediation for environmental issues, to attract students to pursue studies...
Topics: DTIC Archive, West Virginia State University Institute United States, Biofuels, BIOTECHNOLOGY,...
The degeneracy of the genetic code allows nucleic acids to encode amino acid identity as well as noncoding information for gene regulation and genome maintenance. The rare arginine codons AGA and AGG (AGR) present a case study in codon choice, with AGRs encoding important transcriptional and translational properties distinct from the other synonymous alternatives (CGN). We created a strain of Escherichia coli with all 123 instances of AGR codons removed from all essential genes. We readily...
Topics: DTIC Archive, Napolitano,Michael G, Harvard Medical School Boston United States, NUCLEOTIDES,...
The purpose of this project is to develop a novel cell-based assay that is designed to identify compounds for improving mitochondrial function and metabolic disease. The assay utilizes a dual luciferase reporter system to assess translation regulated by 5-UTR sequences. During the reporting period, the originally designed assay was implemented, validated, and optimized successfully. A small compound library (80 compounds) was tested to demonstrate the utility of the assay for phenotypic...
Topics: DTIC Archive, Ja,William, MEDICAL SCREENING, dna sequence analysis, metabolic diseases, genetic...
34
34
Apr 1, 2015
04/15
Apr 1, 2015
by
Dr Emmanuel Mador ,Christian Ogoegbunem Isichei
texts
eye 34
favorite 0
comment 0
This book on the aetiology of preeclampsia-eclampsia has been written keeping in mind the findings of scientists who have researched on the aetiology of this disease which is exclusive to human pregnancy. Research efforts on identifying the cause of preeclampsia have traditionally been focused on subjects that have manifested the disease. Our experience has shown that the culprit that triggers the disease returns to hiding as soon as the disease begins to manifest. In this book care has been...
Topics: Genetic Code, Uric Acid & Preeclampsia, Fetal Biometrics
23
23
2015
2015
2015
by
Cobb, Matthew
texts
eye 23
favorite 3
comment 0
xiv, 434 pages, 16 unnumbered pages of plates : 25 cm
Topics: Genetic code, DNA
9
9.0
2015
2015
2015
by
Cobb, Matthew, author
texts
eye 9
favorite 0
comment 0
xiv, 434 pages, 16 unnumbered pages of plates : 24 cm
Topics: Genetic code, DNA, Genetics -- history, Genetic Phenomena, Genetic Code, Genetiska koden
16
16
2015
2015
2015
by
Ryan, Frank, 1944- author
texts
eye 16
favorite 2
comment 0
ix, 341 pages ; 24 cm
Topics: Human genome -- Popular works, Human genetics -- Popular works, Human genetics, Human genome,...
No abstract available
Topics: NASA Technical Reports Server (NTRS), ASTRONAUTS, HEALTH, MANNED SPACE FLIGHT, PHYSIOLOGICAL...
77
77
Aug 10, 2014
08/14
Aug 10, 2014
by
András Balázs
texts
eye 77
favorite 0
comment 0
In this paper we hope to place the two basic facts of life, constant active self – maintenance and self – reproduction, into a fresh light. The basic idea is considering the genetic assignments as a „biological invariant of motion”, the latter forming a hierarchically produced, „self - constructing”, regressive time inversion symmetry restoration, a closed semantic real – time upbuilding loop. It is, actually, the predetermined future of the biological system. It is this, in fact,...
Topics: The Biological Invariant of Motion, Struggle for Life, Causal Break in Quantum Dynamic, Group...
RNA world theories figure prominently in many scenarios for the origin and early evolution of life. These theories posit that RNA molecules played a much larger role in ancient biology than they do now, acting both as the dominant biocatalysts and as the repository of genetic information. Many features of modern RNA biology are potential examples of molecular fossils from an RNA world, such as the pervasive involvement of nucleotides in coenzymes, the existence of natural aptamers that bind...
Topics: NASA Technical Reports Server (NTRS), BIOCHEMISTRY, BIOSYNTHESIS, PROTEIN SYNTHESIS, RIBONUCLEIC...
The Scottsdale Cure Corridor is more than a place -- it's a collaborative of people, for people, led by Scottsdale Healthcare, Mayo Clinic and TD2 -- the drug development arm of TGen -- the scientists who first cracked the human genetic code. Working together, they are developing breakthrough treatments for cancer that impact people right here in Scottsdale, across the country and around the world.
Topics: Arizona, Scottsdale, City of Scottsdale - Scottsdale Video Network, Government Access TV, Community...
4
4.0
2014
2014
2014
by
Kalquist, Autumn
texts
eye 4
favorite 0
comment 0
324 pages ; 21 cm
Topics: Teenagers -- Fiction, Interplanetary voyages -- Fiction, Genetic code -- Fiction, Dystopias --...
435
435
Aug 24, 2011
08/11
Aug 24, 2011
by
Brian K. Davis
texts
eye 435
favorite 0
comment 0
Amino acids from the same synthesis family are conveyed by related tRNA, cognate with nearest-neighbor codons, within a contiguous region of the genetic code, termed a domain. Its domain structure links genetic code formation with the growth of nascent tRNA-dependent amino acid synthesis pathways. Path-identity elements in these cofactor/adaptor tRNA molecules furnish a pre-synthetase RNA based mechanism for specifically pairing amino acids and their codons.
Topics: genetic code domains, adaptor/cofactor tRNA, RNA code, protein origin
5
5.0
2011
2011
2011
by
Jones, Phill, 1953-
texts
eye 5
favorite 0
comment 0
127 p. : 24 cm
Topic: Genetic code -- Popular works
615
615
Aug 13, 2010
08/10
Aug 13, 2010
audio
eye 615
favorite 1
comment 0
Biology of Belief - A cell biologist and best-selling author is speaking this weekend in Grass Valley. Bruce Lipton wrote "The Biology of Belief" to explain "epi-genetics," which he says is the information "above our genetic code." The Stanford fellow has done research on cloned stem cells and now leads the way in studies of how environment and perception control genes and how we feel. Prop 8 Stay - Same-sex marriages might soon resume in California. The Prop 8...
Topics: KXJZ, Insight, Sacramento public radio, Capital Public Radio, Biology of Belief, The, Bruce Lipton,...
3
3.0
2010
2010
2010
by
Ashe, Joy
texts
eye 3
favorite 0
comment 0
311 pages ; 23 cm
Topics: Genetics -- Fiction, Genetic code -- Fiction, Genetic code, Genetics
The Evolvable Neural Software System (ENSS) is composed of sets of Neural Basis Functions (NBFs), which can be totally autonomously created and removed according to the changing needs and requirements of the software system. The resulting structure is both hierarchical and self-similar in that a given set of NBFs may have a ruler NBF, which in turn communicates with other sets of NBFs. These sets of NBFs may function as nodes to a ruler node, which are also NBF constructs. In this manner, the...
Topics: NASA Technical Reports Server (NTRS), NEURAL NETS, COMPUTER PROGRAMS, HEURISTIC METHODS, GENETIC...
739
739
2008
2008
2008
by
Tropp, Burton E
texts
eye 739
favorite 2
comment 0
xxiv, 1000 pages : 29 cm
Topics: Molecular biology, Molecular Biology, Protein Structure, Biología molecular, Genes, Biologia...
158
158
Oct 18, 2007
10/07
Oct 18, 2007
by
J. Craig Venter
texts
eye 158
favorite 2
comment 0
Topics: Genetic Code, Scientists, Biography & Autobiography, Biography / Autobiography,...
143
143
Oct 6, 2007
10/07
Oct 6, 2007
by
Brian K. Davis
texts
eye 143
favorite 0
comment 0
A model of code evolution that equates the time-order of amino acid entry into the code with synthesis path-length revealed the code has conserved three distinct kinds of transition codes: Ammonium Fixers Code, Expansion Code and Overprinted Code. This established that codon assignments in codes formed prior to the Last Common Ancestor have shaped the 'universal code'.
Topics: amino acid synthesis path-lengths, time-order code addition, genetic code structure
143
143
Oct 6, 2007
10/07
Oct 6, 2007
by
Brian K. Davis
texts
eye 143
favorite 0
comment 0
A model of genetic code evolution that equates the time-order of amino acid entry into the code with synthesis path-length revealed the code conserved three kinds of transition codes: Ammonium Fixers Code, Expansion Code and Overprinted Code. This reveals that not only have nucleotide triplet assignments been strongly conserved between species following divergence from the Last Common Ancestor, but triplet assignments from these earlier transition codes shaped the genetic code.
Topics: amino acid synthesis path-length, time-order code addition, genetic code structure
207
207
Feb 20, 2007
02/07
Feb 20, 2007
by
Brian K. Davis
texts
eye 207
favorite 0
comment 0
A summary is provided of the main features of code evolution revealed by the path-distance model. They illustrate the dependence of code structure on amino acid path-distance. A mechanism is identified for coordinating code evolution with the growh of amino acid synthesis pathways. It is based on evidence of an early reliance on bifunctional tRNA that served as cofactors in amino acid synthesis and adaptors in translation.
Topics: genetic code origin, structural regularities, amino acid path-distance, correlations, bifunctional...
424
424
texts
eye 424
favorite 0
comment 0
Analysis of the conserved trace of tRNA molecules attributed to the last common ancestor, by phylogenetic techniques adapted to pre-divergence evolution, revealed that the genetic code contains domains of nearest-neighbor base triplets read by tRNA adaptors, descended from a common ancestor, that convey amino acids synthesized from a common precursor. This finding provides compelling evidence that tRNA molecules were cofactors in amino acid synthesis, in the era preceding the last common...
Topics: genetic code evolution, coding domains, related tRNA, sibling amino acids, amino acid synthesis...
32
32
2005
2005
2005
by
DeSalle, Rob
texts
eye 32
favorite 2
comment 0
xxiv, 215 pages : 25 cm
Topics: genen, genes, dna, dna sequencing, genoomanalyse, genome analysis, moleculaire genetica, molecular...
769
769
Dec 20, 2004
12/04
Dec 20, 2004
by
Watson, Michael Dal
texts
eye 769
favorite 0
comment 0
Electro-Optic Polymers hold great promise in increased electro-optic coefficients as compared to their inorganic corollaries. Many researchers have focused on quantum chemistry to describe how the dipoles respond to temperature and electric fields. Much work has also been done for single layer films to confirm these results. For optical applications, waveguide structures are utilized to guide the optical waves in 3 layer stacks. Electrode poling is the only practical poling method for these...
Topics: COLONIES, BALLAST (MASS), UPWELLING WATER, SPRINGS (WATER), BACTERIA, CALCITE, BUOYANCY, GENETIC...
113
113
2004
2004
2004
by
Moody, Glyn
texts
eye 113
favorite 1
comment 0
Includes bibliographical references and index
Topics: Genetics, Genomics, Bioinformatics, Genetic code, Computational Biology, Databases, Genetic,...
At the start of the period of the NASA grant three years ago, we had no information on the organization and development of the body axis of the hemichordate, Saccoglossus kowalevskii. Now we have substantial findings about the anteroposterior axis and dorsoventral axis, and based on this information, we have new insights about the origin of chordates from ancestral deuterostomes. We found ways to obtain and preserve large numbers of embryos and hatched juveniles. We can now collect about 40,000...
Topics: NASA Technical Reports Server (NTRS), DATA BASES, EMBRYOS, GENETIC CODE, MARINE BIOLOGY, ANIMALS,...
The idea behind genetic algorithms is to extract optimization strategies nature uses successfully - known as Darwinian Evolution - and transform them for application in mathematical optimization theory to find the global optimum in a defined phase space. One could imagine a population of individual 'explorers' sent into the optimization phase-space. Each explorer is defined by its genes, what means, its position inside the phase-space is coded in his genes. Every explorer has the duty to find a...
Topics: NASA Technical Reports Server (NTRS), BIOLOGICAL EVOLUTION, GENES, GENETIC ALGORITHMS, MUTATIONS,...
We describe a population of colonial cyanobacteria (waterwarts) that develops as the dominant primary producer in a bottom-fed, warm spring in the Cuatro Cienegas karstic region of the Mexican Chihuahuan Desert. The centimeter-sized waterwarts were suspended within a central, conically shaped, 6-m deep well by upwelling waters. Waterwarts were built by an unicellular cyanobacterium and supported a community of epiphytic filamentous cyanobacteria and diatoms but were free of heterotrophic...
Topics: NASA Technical Reports Server (NTRS), COLONIES, UPWELLING WATER, SPRINGS (WATER), BACTERIA,...
106
106
2002
2002
2002
by
Gibson, Greg; Muse, Spencer V., 1966-
texts
eye 106
favorite 1
comment 0
Includes bibliographical references and index
Topics: DNA, Life Sciences - Genetics & Genomics, Genetic Code, Science, Science/Mathematics,...
7
7.0
2001
2001
2001
by
Trainor, Lynn E. H., 1921-
texts
eye 7
favorite 0
comment 0
1 online resource (xvi, 122 pages) :
Topics: Genetics, Genetic code, SCIENCE -- Life Sciences -- Genetics & Genomics
36
36
2001
2001
2001
by
Starkey, Michael P; Elaswarapu, Ramnath
texts
eye 36
favorite 0
comment 0
Includes bibliographical references and index
Topics: Genetics (non-medical), Medical genetics, Molecular biology, Life Sciences - Genetics &...
86
86
2001
2001
2001
by
Davies, Kevin, 1960-
texts
eye 86
favorite 3
comment 0
Includes bibliographical references (p. [253]-296) and index
Topics: Genetics (non-medical), History of specific subjects, Human biology & related topics,...
16
16
2001
2001
2001
by
Alcamo, I. Edward
texts
eye 16
favorite 1
comment 0
1 online resource (xii, 348 pages) :
Topics: moleculaire biologie, molecular biology, Nucleic Acids, mens, man, moleculaire genetica, molecular...
147
147
Dec 1, 2000
12/00
Dec 1, 2000
by
Arnaud, Sara B.; Grindeland, R. E
texts
eye 147
favorite 0
comment 0
The bones of the feet are likely to lose mineral during spaceflight because they are not functioning to support body weight in space. Although loss of bone from the heel bone (calcaneus) during spaceflight is well documented, loss of mineral from other bones in the feet of astronauts has not been quantified. A possibly vulnerable candidate is the metatarsal, which, as a weight-bearing bone in runners, is vu I nerable to stress fractures. To explore the potential for bones of the feet to lose...
Topics: MATHEMATICAL MODELS, BIOCHEMISTRY, NETWORK ANALYSIS, GENETIC CODE, BIOLOGICAL EVOLUTION,...
We provide preliminary evidence that existing algorithms for inferring small-scale gene regulation networks from gene expression data can be adapted to large-scale gene expression data coming from hybridization microarrays. The essential steps are (I) clustering many genes by their expression time-course data into a minimal set of clusters of co-expressed genes, (2) theoretically modeling the various conditions under which the time-courses are measured using a continuous-time analog recurrent...
Topics: NASA Technical Reports Server (NTRS), GENE EXPRESSION, GENES, GENETIC CODE, GENETICS, BIOLOGICAL...
68
68
2000
2000
2000
by
Kay, Lily E
texts
eye 68
favorite 4
comment 0
xix, 441 pages : 24 cm
Topics: Genetic code -- Research -- History, Code génétique -- Recherche -- Histoire, Genetic code --...
Source: removedNEL
28
28
2000
2000
2000
by
Kay, Lily E
texts
eye 28
favorite 0
comment 0
xix, 441 pages : 24 cm
Topics: Genetic code -- Research -- History, Code génétique -- Recherche -- Histoire, Genetic code --...
Source: removedNEL
